What Does DMPK In Drug Discovery Means?

 

Drug discovery consists of a wide array of methods. It takes 10-12 years on average and costs approximately USD 2 billion to launch a new viable drug in the market. Scientists at a contract research organization apply several qualitative and quantitative analyses to deliver lead drug candidates in the shortest time frame possible. DMPK (Drug Metabolism and Pharmacokinetics) is one of the most vital parts of drug discovery services.

What is DMPK (Drug Metabolism and Pharmacokinetics)?

Drug metabolism and pharmacokinetics methods help to determine the promising drug candidates for further investigation and development processes. DMPK studies are performed by contract research organizations in India throughout the drug development processes to determine the pharmacological characteristics of a compound such as absorption, distribution, metabolism, excretion (ADME), and pharmacokinetic characteristics.

Drug Metabolism: The metabolism process is the breaking of an administered drug molecule into relevant and effective compounds throughout the body. This modification process is carried out with the help of drug modifying enzymes (DME). Usually, drug metabolism happens at numerous locations in the body, but the liver is the primary organ responsible for the modification and removal of drug compounds.

Pharmacokinetics: It's a collection of pharmacological methods to assess how much drug remains throughout the human body over time. Various tests are needed to be performed by researchers at contract research organizations for measuring a drug’s ADME properties. It helps in understanding how the drug affects the body once it is administered. ADME properties provide deeper insights regarding the function of drugs and help to determine the optimal amount for dosage.

  • Absorption studies help to understand how the drug moves from the site of administration into the bloodstream.
  • Distribution based assays help in assessing the route a drug takes to reach the intended target site.
  • Metabolism characteristics of a drug candidate involve modification to it by bodily organs or enzymes.
  • Excretion based assays help drug discovery experts to know how a drug is getting removed from the body.

Need To Outsource Drug Discovery Projects? Get In Touch With Integral Biosciences 

Outsource your drug development projects to one of the most prominent drug discovery contract research organizations in India, that is, Integral Biosciences. Partnering with IBS means partnering with the best minds to achieve your drug discovery objectives. Get in touch with IBS now.

Location: India

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